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Biogenics Research Institute
Other Respiratory Tract Disorders
Hypersensitivity Pneumonitis
Idiopathic Intersitial Lung Disease

The Research Team
Robert L. Jacobs, MD
Principal Investigator

Robert L. Jacobs, MD entered the United States Air Force after graduation from high school. He was trained by the Air Force in Primary and Advanced Russian Studies at Syracuse University and in Cryptoanalytical Studies at Goodfellow AFB, Texas. He served within the Air Force Intelligence Service, a branch of NSA, during the height of the "Cold War", monitoring the Russian ICBM missile ranges and space program. He was in the European theatre during the Cuban Missile Crisis and erection of the Berlin Wall. He left the military to attend the Medical College of Alabama, graduating in 1968. He served a rotating internship at Malcomb Grow USAF Medical Center in Washington, D.C., and a residency in internal medicine and a fellowship in allergy/immunology at Wilford Hall USAF Medical Center in San Antonio, Texas.

He was assigned a staff positon in the Allergy/Immunology Department and moved up to become the Chairman and Training Program Director, Consultant to the Surgeon General in Internal Medicine and Allergy/Immunology, and Special Assistant to the Surgeon General concerning facilities and staffing associated with allergy services worldwide. During his tenure as Chairman and Director of the Training Program, he designed the physical plant within Wilford Hall Medical Center currently housing the Allergy/Immunology Department with the foresight to predict the growth of Immunology within the field and to be prepared with adequate training slots and facilities for the staff to be able to maintain an excellence that the Allergy/Immunology Department continues to achieve. During this period, Dr. Jacobs and staff designed and wrote the guidelines of the modern training programs for Allergy/Immunology which remains the criteria that training programs must meet. Clinical Research, however, became the driving passion for Dr. Jacobs as the field of Allergy/Immunology became scientifically-based. Clinical studies on chronic nasal disease, drug interactions, adverse responses to immunizations, and insect sting reactions were carried out during the tenure at Wilford Hall Medical Center.


For most of his professional life, Dr. Jacobs has been involved with a group of diseases that are the most frustrating within the field of pulmonary medicine, the idiopathic interstitial lung diseases. By investigating the environments of these patients, Dr. Jacobs has shown that most of these difficult problems are caused by exposure to organic dusts within closed spaces, usually the home.  This publication has been selected by the pulmonary journal, Chest, as the second most important work on interstitial lung disease in the recent past. Dr. Jacobs has several publications concerning these problems. He has been honored with a lifetime achievement award for his work with patients with these disorders by the San Antonio Business Journal in collaboration with University Health System, University of the Incarnate Word, and others.


Dr. Jacobs was formerly the managing partner of a busy clinical practice of allergy and asthma management with thousands of patients. He, along with his wife and children, established Biogenics Research Institute for the study of allergic, immunologic, and chronic respiratory tract diseases. This institute is considered one of the top  research sites for clinical drug trials in respiratory tract diseases in the United States.


Dr. Jacobs continues to work very hard to maintain an excellence in the field of allergy, asthma, and clinical immunology in the clinical and research settings. He expects similar efforts from those around him.



Daniel A. Ramirez, MD
Principal Investigator

Daniel A. Ramirez, M.D. started his scientific career as an Electrical Engineer in 1998. He worked for the U.S. Navy as a computer and underwater range engineer at Roosevelt Roads Naval Base in Puerto Rico. He then graduated with honors from the University of Puerto Rico school of Medicine in 1973 and trained in internal medicine at Letterman Army Medical Center in San Francisco, California. He did an allergy / immunology fellowship at Walter Reed Army Medical Center in Washington, D.C. where he did research on anaphylaxis and reactions to hymenoptera (stings of bees, yellow jackets and hornets.)


He was assigned as Chief of Allergy-Immunology at Brooke Army Medical Center (BAMC) in 1979. While at BAMC, he became interested in mountain cedar allergy, since it affects many in South Texas, even people without any other allergy.


Dr. Ramirez formerly owned a large, busy allergy/immunology practice in San Antonio and has been involved in many clinical research projects in allergy, asthma, other respiratory and skin diseases. 


Dr. Ramirez's interests out of medicine include computer programming, woodworking, digital photography and music. He is a very proud "Aggie Dad" of two Texas A&M graduates. His oldest son is also an allergist/immunologist and has joined his dad's private practice. His daughter is a lawyer.

Robert Ramirez, M.D.

Robert Ramirez went to medical school at the University of Puerto Rico School of Medicine, where he graduated with honors in 2003. From there he went on to train in Internal Medicine at the University of Texas Health Science Center in San Antonio. His clinical and interpersonal skills were recognized by the medical school by awarding him one of three Best Resident awards in 2005. Despite the time constraints and challenges imposed by his residency training, he was able to perform basic science research in immunology. His work on chemokines and multiple sclerosis was presented at a South Texas American College of Physicians meeting.

Subsequently, his passion for respiratory and immunological diseases took him to the University of Texas Medical Branch in Galveston, Texas, to seek training in Allergy & Immunology. While there, he had the opportunity to hone his clinical skills, while staying heavily involved in asthma research. He formed part of clinical studies organized by the NIH's Asthma Clinical Research Network. His basic science work on glucocorticoid receptor function was presented at the American Thoracic Society and the American College of Allergy, Asthma and Immunology national meetings.

Since completing his training and obtaining his board certification in Allergy & Immunology in 2009, he has aimed to balance an active clinical practice and a stimulating research career. He joined Biogenics Research Institute in 2012 with this goal in mind.

Dr. Ramirez also enjoys many hobbies including golfing, playing the guitar and drums, and running. He and his wife, Carmen, are the parents of two daughters.

Frank O. Jacobs, BS, MT, CCRC
Support Staff

Frank serves as the Clinical Research Manager and senior Study Coordinator for Biogenics Research Institute. He and Dr. Jacobs originally founded the company in 1993. Prior to that time, Frank had been involved in other human research activities. After graduating from the University of Texas Health Science Center in San Antonio, Frank worked in aerospace physiology research at Brooks Air Force Base, conducting military-contracted studies involving decompression sickness, G-tolerance, thermal stress, and wound healing in Air Force pilot candidates. In 1988, Frank moved to Houston to work as a research contractor for NASA at Johnson Space Center. His position as a Flight Experiment Scientist allowed him to develop and implement research protocols for Shuttle-based Spacelab missions as well as provide training and collect data on Shuttle astronauts during spaceflight.

Frank returned to San Antonio in late 1992 to work with his father and sister in establishing Biogenics. He received and has maintained his certification as a clinical research coordinator since 1997. Frank has two sons who both graduated college with degrees in Physics.  

Nicole J. Skelton, BA, BSN, CCRC
Support Staff

Nicole earned a Bachelor of Arts degree from Texas A&M University in 1992 majoring in Speech Communications. She has been involved as a clinical research coordinator for the past 26 years starting as an assistant working at Biogenics,  participating in the very first study with Biogenics in 1993.  She came on board full-time as a research coordinator in 1995.   After two years as a full-time coordinator, Nicole attended nursing school to have more of a medical-oriented background.  She graduated in 2000 with a Bachelor of Science in Nursing degree from The University of Texas Health Science Center. Nicole became certified as a clinical research coordinator in 1998. She has used her marketing skills to promote our research facility broadening the base of companies that rely upon Biogenics to deliver study results at the highest level.


Nicole has one teenage son in high school and one son in middle school.  She enjoys watching her sons play sports.  Their three personal dogs plus fostering dogs and puppies for God's Dogs Rescue continually keep this family busy.


RaeAnn Jacobs,CRC
Support Staff
RaeAnn joined the Biogenics Research Institute team in 2014 after moving to San Antonio, TX from Dallas, TX.

Her attention to detail has helped out immensely in numerous clinical trials.  Her background in accounting showed that she would make an excellent study coordinator.

RaeAnn enjoys doing activities with her 3 children and husband.  She always keeps busy in her spare time refurbishing furniture and working in the countryside.

Kandyce Woodard, M.A.
Support Staff

Kandyce began working with Biogenics Research Institute and Biogenics Research Chamber in May 2019.  She has a wonderful rapport with all patients and is an excellent phlebotomist.

Kandyce is a busy mother of two children.  She enjoys fishing and riding her motorcycle in her spare time.

Tracye Jackson, Brandy Walker & Candy Johnson,
Support Staff

These 3 lovely medical assistants joined Biogenics Research Institute in our laboratory in 2014.  They make the study patients feel at ease and are all excellent phlebotomists! 

Kathy Marotta, CCRC
Support Staff
Kathy earned her degree in Clinical Research in 2010. She did an internship at UT Health Science Center, which eventually lead into a job working as a Clinical Research Coordinator in Pulmonary Research at University Hospital and the VA Hospital. She has been involved in studies working with Diabetes, Hypertension, Infectious Disease and Infection Control, COPD, Asthma and Allergies.
Kathy works as a contract employee for Biogenics as a certified clinical research coordinator.
Kathy is married and has 3 children. During her spare time she enjoys spending it with her family out at the lake, doing outdoor activities, reading, and scrapbooking.